PMID: 22005837

Valque H, Gouyer V, Husson MO, Gottrand F, Desseyn JL
Abnormal expression of Muc5b in Cftr-null mice and in mammary tumors of MMTV-ras mice.
Histochem Cell Biol. 2011 Dec;136(6):699-708. Epub 2011 Oct 18., [PubMed]
Sentences
No. Mutations Sentence Comment
53 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 22005837:53:51
status: NEW
view ABCC7 p.Ser489* details
 The Cftr-knockout mice used are homozygous for the S489X-CFTR mutation (B6;129-Cftr tm1Unc) (Snouwaert et al. 1992). Login to comment 54 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 22005837:54:4
status: NEW
view ABCC7 p.Ser489* details
 The S489X mouse third-generation backcross to C57BL/6 were maintained at the French Centre of Transgenesis, Archiving and Animal Models in Orléans (MF Bertrand, CDTA, Orléans, France) by random mating of heterozygous mice and were obtained with their wild-type littermates (Freedman et al. 1999) at 21-25 days of age. Cftr¡/¡ mice may die shortly after weaning because of intestinal obstruction, and both Cftr¡/¡ and Cftr+/+ mice received polyethylene glycol 4000 added to the drinking water (44.4 g/l) to increase the survival of the Cftr¡/¡ mice. Login to comment