ABCMdb

PMID: 21968975

Palaniyandi K, Zhao Q, Chang XB
Infection of H69AR cells with retroviral particles harboring interfering RNAi significantly reduced the multidrug resistance of these small cell lung cancer cells.
Int J Biochem Mol Biol. 2011;2(2):155-167. Epub 2011 Apr 22., [PubMed]

Sentences

No. Mutations Sentence Comment

52 ABCC1 p.Lys1333Leu In order to test whether this is the consequence of MRP1-mediated substrate-GSH co-transport, the GSH contents in BHK cells expressing human CFTR, human MRP1 and K1333L-mutated MRP1 were determined. Login to comment 53 ABCC1 p.Lys1333Leu ABCC1 p.Lys1333Leu The results in Figure 2A clearly indicate that the GSH content in BHK/K1333L cell is similar to that of BHK/ CFTR, but significantly higher than that in BHK/ MRP1 cell, suggesting that wt MRP1 constantly pumps the GSH out of the cell whereas the functionally inactive K1333L mutant [14] cannot. Login to comment 80 ABCC1 p.Lys1333Leu Total intracellular GSH was determined in triplicate [n = 55 (CFTR), 4 (K1333L), 65 (MRP1), 50 (H69) and 50 (H69AR)] according to the method described in Materials and Methods. Login to comment