PMID: 21940661

Stahl M, Stahl K, Brubacher MB, Forrest JN Jr
Divergent CFTR orthologs respond differently to the channel inhibitors CFTRinh-172, glibenclamide, and GlyH-101.
Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C67-76. doi: 10.1152/ajpcell.00225.2011. Epub 2011 Sep 21., [PubMed]
Sentences
No. Mutations Sentence Comment
219 ABCC7 p.Thr338Ala
X
ABCC7 p.Thr338Ala 21940661:219:89
status: NEW
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ABCC7 p.Phe337Ala
X
ABCC7 p.Phe337Ala 21940661:219:79
status: NEW
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 Gupta et al. (21) observed that two mutations in the 6th transmembrane region, F337A and T338A, significantly weakened glibenclamide block. Login to comment 231 ABCC7 p.Arg347Asp
X
ABCC7 p.Arg347Asp 21940661:231:12
status: NEW
view ABCC7 p.Arg347Asp details
 Indeed, the R347D mutation alters ATPase activity in the NBDs, suggesting that R347 might be involved in conformational coupling between the TMDs and the NBDs (26). Login to comment