PMID: 21878834

Bouamar R, Hesselink DA, van Schaik RH, Weimar W, van der Heiden IP, de Fijter JW, Kuypers DR, van Gelder T
Mycophenolic acid-related diarrhea is not associated with polymorphisms in SLCO1B nor with ABCB1 in renal transplant recipients.
Pharmacogenet Genomics. 2012 Jun;22(6):399-407. doi: 10.1097/FPC.0b013e32834a8650., [PubMed]
Sentences
No. Mutations Sentence Comment
165 ABCC2 p.Gly699Ala
X
ABCC2 p.Gly699Ala 21878834:165:1927
status: NEW
view ABCC2 p.Gly699Ala details
 For example, recently, Liu Table 5 Dose-adjusted mycophenolic acid-area under the curve in patients using cyclosporine as comedication according to ABCB1 and SLCO genotypes Dose-adjusted MPA-AUC (mg.h/l) ± SD n (%) Day 3 Day 10 Month 1 Month 3 Month 6 Month 12 ABCB1 1236C > T CC 55 (33) 31 ± 10 29 ± 13 34 ± 12 41 ± 15 48 ± 14 46 ± 16 CT 84 (51) 31 ± 10 31 ± 12 34 ± 17 44 ± 23 49 ± 24 48 ± 21 TT 27 (16) 36 ± 16 30 ± 10 32 ± 11 41 ± 16 46 ± 14 45 ± 16 2677G > T/A GG 53 (31) 32 ± 10 30 ± 14 35 ± 13 43 ± 17 50 ± 15 45 ± 16 GT/TT 111 (65) 32 ± 12 31 ± 12 33 ± 16 43 ± 21 48 ± 21 48 ± 19 GA 6 (4) 30 ± 5 23 ± 3 27 ± 9 25 ± 10 35 ± 5 49 ± 10 3435C > T CC 36 (22) 32 ± 8 28 ± 9 32 ± 10 41 ± 15 48 ± 15 43 ± 16 CT 90 (54) 31 ± 11 30 ± 12 35 ± 17 43 ± 23 48 ± 22 47 ± 18 TT 40 (24) 33 ± 14 33 ± 14 33 ± 11 43 ± 16 48 ± 17 49 ± 20 SLCO1B1 T521C CC 8 (5) 38 ± 15 29 ± 8 37 ± 24 47 ± 19 54 ± 10 45 ± 13 TC 49 (29) 31 ± 12 29 ± 12 33 ± 19 43 ± 29 50 ± 25 50 ± 26 TT 110 (66) 32 ± 10 31 ± 13 34 ± 12 42 ± 15 47 ± 17 47 ± 17 A388G AA 48 (29) 30 ± 9 27 ± 8 30 ± 12 36 ± 12 42 ± 15 45 ± 16 AG 67 (40) 33 ± 13 32 ± 14 35 ± 17 44 ± 17 49 ± 16 48 ± 17 GG 46 (27) 32 ± 9 32 ± 13 35 ± 15 45 ± 25 51 ± 24 45 ± 20 SLCO1B3 T344G GG 111 (66) 31 ± 10 29 ± 12 33 ± 15 41 ± 17 45 ± 18 49 ± 21 GT 51 (31) 33 ± 13 33 ± 13 36 ± 14 48 ± 26 56 ± 22 46 ± 17 TT 5 (3) 37 ± 14 33 ± 8 26 ± 9 39 ± 17 52 ± 5 43 ± 14 G699A AA 110 (66) 31 ± 10 29 ± 12 33 ± 15 41 ± 17 45 ± 18a 48 ± 19 GA 50 (30) 33 ± 14 33 ± 13 37 ± 14 49 ± 26 56 ± 22 46 ± 17 GG 5 (3) 37 ± 14 33 ± 8 26 ± 9 39 ± 17 52 ± 5 43 ± 14 MPA-AUC, mycophenolic acid-area under the curve; SD, standard deviation. a Significant (P < 0.05). Login to comment