PMID: 21799461

Ufer M, von Stulpnagel C, Muhle H, Haenisch S, Remmler C, Majed A, Plischke H, Stephani U, Kluger G, Cascorbi I
Impact of ABCC2 genotype on antiepileptic drug response in Caucasian patients with childhood epilepsy.
Pharmacogenet Genomics. 2011 Oct;21(10):624-30., [PubMed]
Sentences
No. Mutations Sentence Comment
102 ABCC2 p.Val417Ile
X
ABCC2 p.Val417Ile 21799461:102:33
status: NEW
view ABCC2 p.Val417Ile details
 Previously, the ABCC2 1249G > A (Val417Ile) polymorphism has been shown to be associated with lower oral bioavailability and increased clearance of the ABCC2 substrates, talinolol [16] and irinotecan in vivo [30], suggesting increased efflux activity of variant allele carriers. Login to comment