PMID: 21792076

Pankratz VS, Sun Z, Aakre J, Li Y, Johnson C, Garces YI, Aubry MC, Molina JR, Wigle DA, Yang P
Systematic evaluation of genetic variants in three biological pathways on patient survival in low-stage non-small cell lung cancer.
J Thorac Oncol. 2011 Sep;6(9):1488-95., [PubMed]
Sentences
No. Mutations Sentence Comment
130 ABCC4 p.Lys304Asn
X
ABCC4 p.Lys304Asn 21792076:130:163
status: NEW
view ABCC4 p.Lys304Asn details
 Evidence shows that ABCC4 has very important roles in the pharmacogenetics of cancer33; for example, in childhood acute lymphoblastic leukemia (T-1393C and A934C [Lys304Asn] polymorphisms)34 and with cyclophosphamide-induced adverse drug reactions in patients with breast cancer (rs9561778).35 Among the 63 tag-SNPs analyzed from ABCC4 in our study, rs1729786 was found to be significantly associated with OS of LS-NSCLC; similar to rs3768490, rs1729786 is intronic, and its functional significance needs to be further elucidated. Login to comment