PMID: 21712022

Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M
Loss of CFTR Affects Biliary Epithelium Innate Immunity and Causes TLR4-NF-kappaB-Mediated Inflammatory Response in Mice.
Gastroenterology. 2011 Oct;141(4):1498-1508.e5. Epub 2011 Jun 26., [PubMed]
Sentences
No. Mutations Sentence Comment
25 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 21712022:25:218
status: NEW
view ABCC7 p.Ser489* details
 Animals and Experimental Protocol Experiments were performed according to protocols approved by the Yale University Institutional Animal Care and Use Committee. Congenic B6.129P2-Cftrtm1Unc mice (harboring a mutation, S489X, blocking CFTR transcription) and their WT littermates were used as an accepted model for the human CF disease.13 Genotyping for each mouse and breeding were performed as described14,15 (see Supplementary Materials and Methods). Login to comment 47 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 21712022:47:59
status: NEW
view ABCC7 p.Ser489* details
 Congenic B6.129P2-Cftrtm1Unc mice, (harbouring a mutation, S489X, blocking CFTR transcription), and their wild type littermates were used as an accepted model for the human CF disease13 . Login to comment