ABCMdb

PMID: 21701864

de Foresta B, Vincent M, Garrigos M, Gallay J
Transverse and tangential orientation of predicted transmembrane fragments 4 and 10 from the human multidrug resistance protein (hMRP1/ABCC1) in membrane mimics.
Eur Biophys J. 2011 Sep;40(9):1043-60. Epub 2011 Jun 24., [PubMed]

Sentences

No. Mutations Sentence Comment

61 ABCC1 p.Thr556Ala ABCC1 p.Thr550Ala ABCC1 p.Tyr568Ala Mutations resulting in the replacement of two of its threonine residues (T550A and T556A) modulated the drug-resistance profile of hMRP1 and a mutation affecting the tyrosine residue (Y568A) reduced the affinity of hMRP1 for E217bG (Zhang et al. 2006). Login to comment 62 ABCC1 p.Trp553Ala ABCC1 p.Pro557Ala In addition, mutations affecting the single proline (P557A) or the single Trp (W553A) residue decreased the transport of various organic anion substrates (Koike et al. 2002, 2004). Login to comment 79 ABCC1 p.Cys148Ser ABCC1 p.Cys555Ser ABCC1 p.Cys563Ser Mutations introduced: C148S in mTM4, C555S and C563S in mTM10 Materials and methods Chemicals We obtained n-dodecyl-b-D-maltoside (DDM) from Calbiochem. Login to comment