PMID: 21589945

Klepsch F, Chiba P, Ecker GF
Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein.
PLoS Comput Biol. 2011 May;7(5):e1002036. Epub 2011 May 12., [PubMed]
Sentences
No. Mutations Sentence Comment
138 ABCB1 p.Leu175Cys
X
ABCB1 p.Leu175Cys 21589945:138:110
status: NEW
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ABCB1 p.Asn820Cys
X
ABCB1 p.Asn820Cys 21589945:138:120
status: NEW
view ABCB1 p.Asn820Cys details
 In addition, a recent cross-linking study further strengthened this by showing that an M1M cross-link between L175C and N820C did not prevent verapamil and rhodamine B to be transported [46]. Login to comment 244 ABCC1 p.Phe728Cys
X
ABCC1 p.Phe728Cys 21589945:244:150
status: NEW
view ABCC1 p.Phe728Cys details
 Loo et al. also demonstrated that binding of vinblastine, cyclosporin A and rhodamine B could prevent the formation of a cross-link between L339C and F728C, suggesting that the ligands are at least partially located between these two residues [52]. Login to comment