ABCMdb

PMID: 21586796

Beers MF, Hawkins A, Shuman H, Zhao M, Newitt JL, Maguire JA, Ding W, Mulugeta S
A novel conserved targeting motif found in ABCA transporters mediates trafficking to early post-Golgi compartments.
J Lipid Res. 2011 Aug;52(8):1471-82. Epub 2011 May 17., [PubMed]

Sentences

No. Mutations Sentence Comment

166 ABCA3 p.Leu101Pro Most prominent of these was L101P, which, when transfected into similar cell lines, produced profound ER retention. Login to comment 167 ABCA3 p.Leu101Pro ABCA3 p.Asn568Asp Most prominent of these was L101P, which, when transfected into similar cell lines, produced profound ER retention. Login to comment 168 ABCA3 p.Asn568Asp In addition to this trafficking mutant, another mutant, N568D, was in fact trafficked to lysosomes but failed to concentrate NBD-phosphaty- dilcholine in this compartment. Login to comment 192 ABCA3 p.Leu101Pro However, like L101P, xLxxKN mutations would naturally affect functional outcome if the transporters were held from reaching their destined compartments. Login to comment 193 ABCA3 p.Leu101Pro However, like L101P, xLxxKN mutations would naturally affect functional outcome if the transporters were held from reaching their destined compartments. Login to comment