PMID: 21470105

Honorat M, Falson P, Terreux R, Di Pietro A, Dumontet C, Payen L
Multidrug resistance ABC transporter structure predictions by homology modeling approaches.
Curr Drug Metab. 2011 Mar;12(3):268-77., [PubMed]
Sentences
No. Mutations Sentence Comment
290 ABCG2 p.His457Ala
X
ABCG2 p.His457Ala 21470105:290:27
status: NEW
view ABCG2 p.His457Ala details
ABCG2 p.His457Ala
X
ABCG2 p.His457Ala 21470105:290:53
status: NEW
view ABCG2 p.His457Ala details
ABCG2 p.Lys452Ala
X
ABCG2 p.Lys452Ala 21470105:290:44
status: NEW
view ABCG2 p.Lys452Ala details
 The mutations of Lys452 or His457 into Ala (K452A or H457A) markedly increased the transport secretion of well known substrates of ABCG2 (mitoxantrone, BODIPY-prazosin, and Hoechst33342). Login to comment