PMID: 21468756

Chew SC, Singh O, Chen X, Ramasamy RD, Kulkarni T, Lee EJ, Tan EH, Lim WT, Chowbay B
The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients.
Cancer Chemother Pharmacol. 2011 Jun;67(6):1471-8. Epub 2011 Apr 6., [PubMed]
Sentences
No. Mutations Sentence Comment
62 ABCB1 p.Gly141Lys
X
ABCB1 p.Gly141Lys 21468756:62:1212
status: NEW
view ABCB1 p.Gly141Lys details
 AUC0-inf, area under plasma concentration-time curve from time zero to infinity; CL plasma clearance (Whiskers: 5-95 percentile) Table 1 Allele frequencies of CYP3A4, CYP3A5, ABCC2, ABCG2 and SLCO1B3 in healthy Asian populations, NPC patients and comparisons with Caucasians SNPs rs ID Allele Allelic frequencies Chinese Malays Indians Caucasians NPC patients CYP3A4 (UCSC accession number NM_017460) CYP3A4*1B rs2740574 A 1 1 1 0.98 1 G 0 0 0 0.02 0 IVS6-191C [ T rs35599367 C 1 1 1 0.95 [2] 1 T 0 0 0 0.05 0 CYP3A5 (Ensembl gene ID ENSG00000106258) CYP3A5*3 rs776746 A 0.24 0.39 0.41 0.15 [7] 0.33 G 0.76 0.61 0.59 0.85 0.67 CYP3A5*6 rs10264272 G 1 1 1 1 [7] 1 A 0 0 0 0 0 ABCB1 (UCSC accession number NM_000927) 1236C [ T rs1128503 C 0.28 0.34 0.33 0.59 [15] 0.36 T 0.72 0.66 0.67 0.41 0.64 2677G [ A/T rs2032582 G 0.38 0.53 0.33 0.56 [15] 0.51 (Ala893Ser/Thr) A 0.12 0.03 0.07 0.02 0.10 T 0.5 0.44 0.6 0.42 0.39 3435C [ T rs1045642 C 0.47 0.49 0.63 0.46 [15] 0.66 T 0.53 0.51 0.37 0.54 0.34 ABCC2 (UCSC accession number NM_000392) *?9383C [ G rs12762549 C 0.4 0.4 0.55 NA 0.40 G 0.6 0.6 0.45 NA 0.60 ABCG2 (UCSC accession number NM_004827) 421C [ A rs2231142 C 0.72 [25] 0.73 [25] 0.85 [25] 0.88 [16] 0.71 (Gly141Lys) A 0.28 0.27 0.15 0.12 0.29 SLCO1B3 (UCSC accession number NM_019844) 334T [ G rs4149117 T 0.35 0.2 0.08 0.15 [14] (Ser112Ala) G 0.65 0.8 0.92 0.86 439A [ G rs57585902 A 1 1 1 0.995 [14] 1 (Thr147Ala) G 0 0 0 0.005 0 699G [ A rs7311358 G 0.36 0.19 0.1 0.16 [14] 0.24 (Met233Ile) A 0.64 0.81 0.9 0.84 0.76 767G [ C rs60140950 G 1 0.96 0.95 0.81 [14] 1 (Gly256Ala) C 0 0.04 0.05 0.19 0 1559A [ C NA A 1 1 1 1 [14] 1 (His520Pro) C 0 0 0 0 0 1564G [ T rs72559743 G 1 1 1 0.98 [5] 1 (Gly522Cys) T 0 0 0 0.02 0 1679T [ C rs12299012 T 1 1 1 0.98 [14] 1 (Val560Ala) C 0 0 0 0.02 0 IVS12-5676A [ G rs11045585 A 0.82 0.82 0.97 NA 0.78 G 0.18 0.18 0.03 NA 0.22 NA not available The genotype and allele frequencies of CYP3A4*1B, CYP3A5*3, ABCB1 1236C [ T, 2677G [ T/A, 3435C [ T in healthy Asian subjects are available in the previous publication [11] nadir haemoglobin from cycle 1 baseline compared to those with GG (n = 14) or TT (n = 8) genotypes [median (range); percentage decrease in nadir haemoglobin from cycle 1 baseline (%); GA ? Login to comment