PMID: 21451505

Franke RM, Lancaster CS, Peer CJ, Gibson AA, Kosloske AM, Orwick SJ, Mathijssen RH, Figg WD, Baker SD, Sparreboom A
Effect of ABCC2 (MRP2) transport function on erythromycin metabolism.
Clin Pharmacol Ther. 2011 May;89(5):693-701. Epub 2011 Mar 30., [PubMed]
Sentences
No. Mutations Sentence Comment
55 ABCC2 p.Val417Ile
X
ABCC2 p.Val417Ile 21451505:55:551
status: NEW
view ABCC2 p.Val417Ile details
ABCC2 p.Cys1515Tyr
X
ABCC2 p.Cys1515Tyr 21451505:55:736
status: NEW
view ABCC2 p.Cys1515Tyr details
 (b) Correlation of observed 14CO2 production over the course of 1 h from the same patients, with predicted values obtained from a binomial equation originally derived from data obtained in healthy volunteers.23 Table 1  Description and allele frequencies of the investigated ABCC2 variants ABCC2 genotype Position Effecta Functionb NCBI ID p q ABCC2 -1549G>A 5'-Flanking - Unknown rs1885301 0.843 0.157 ABCC2 -1019A>G 5'-Flanking - Unknown rs2804402 0.617 0.383 ABCC2 -24C>T 5' UTR - Decreased rs717620 0.832 0.168 ABCC2 1249G>A Exon 10 V417I Unknown rs2273697 0.791 0.209 ABCC2 IVS26 -34T>C Intron 26 Exon 26 Unknown rs8187698 0.939 0.061 ABCC2 3972C>T Exon 28 I1324I Unknown rs3740066 0.640 0.360 ABCC2 4544G>Ac Exon 32 C1515Y Unknown rs8187710 0.971 0.029 Hardy-Weinberg notation for allele frequencies. Login to comment