ABCMdb

PMID: 21392722

Hoenig MR, Walker PJ, Gurnsey C, Beadle K, Johnson L
The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort.
J Clin Lipidol. 2011 Mar-Apr;5(2):91-6. Epub 2011 Jan 13., [PubMed]

Sentences

No. Mutations Sentence Comment

67 ABCG8 p.Asp19His For example, the apoE4/4 genotype, which is associated with lesser percent LDL-C reduction with atorvastatin compared to the apoE3/3 genotype,14 is also associated with greater cholesterol absorption and lower cholesterol synthesis.15,16 Similarly, the D19H polymorphism in ABCG8, which is associated with lower cholesterol absorption,17 may be a predictor of increased LDL-C response to atorvastatin.18 However, a limitation of using cholesterol metabolism markers to predict atorvastatin response is that this strategy does not take into account variation in drug metabolism and drug disposition.3 In this context, our finding that the C3435T polymorphisms in ABCB1, which has been associated with altered atorvastatin pharmacokinetics,8 is associated with variation in atorvastatin efficacy independently of variation in cholesterol metabolism raises the possibility that it may be possible to use pharmacogenomic strategies to complement a cholesterol metabolism marker strategy. Login to comment