PMID: 21338920

Sampson HM, Robert R, Liao J, Matthes E, Carlile GW, Hanrahan JW, Thomas DY
Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR.
Chem Biol. 2011 Feb 25;18(2):231-42., 2011-02-25 [PubMed]
Sentences
No. Mutations Sentence Comment
152 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 21338920:152:56
status: NEW
view ABCC7 p.Gly551Asp details
ABCC7 p.Val1293Gly
X
ABCC7 p.Val1293Gly 21338920:152:70
status: NEW
view ABCC7 p.Val1293Gly details
 This hypothesis is consistent with the finding that the G551D and the V1293G mutations alter the affinity of these molecules for CFTR (Moran et al., 2005; Zegarra-Moran et al., 2007). Login to comment