ABCMdb

PMID: 21282443

Lignell A, Lowdin E, Cars O, Sanglard D, Sjolin J
Voriconazole-induced inhibition of the fungicidal activity of amphotericin B in Candida strains with reduced susceptibility to voriconazole: an effect not predicted by the MIC value alone.
Antimicrob Agents Chemother. 2011 Apr;55(4):1629-37. Epub 2011 Jan 31., [PubMed]

Sentences

No. Mutations Sentence Comment

83 ABCB1 p.Arg467Lys Summary of drug MICs and mechanisms of resistance to voriconazole for the Candida strains Candida species and strain Name in this study MIC (mg/liter) of: Voriconazole resistance mechanisms Voriconazole Amphotericin B C. albicans C26 CA1MIC8 8 0.5 Increase in CDR1 and CDR2 mRNAs; mutations of ERG11: S405F and Y132H (26) C. albicans C40 CA2MIC8 8 0.5 Increase in MDR1 mRNA; mutations of ERG11: G464S, R467K, and Y132H (26) C. albicans C56 CA3MIC2 2 0.5 Increase in CDR1 and CDR2 mRNAs; mutations of ERG11: G129A and G464S (26) C. albicans 20288.030 CA4MIC256 256 0.5 Increase in CDR1 mRNA; upregulation of ERG11 C. glabrata B346 4018 CG1MIC0.5 0.5 0.5 NAa C. glabrata 263 SMI CG2MIC4 4 0.5 NA C. krusei B336 4026 CK1MIC0.5 0.5 0.5-1 NA C. krusei 20550.054 CK2MIC4 4 0.5 NA C. albicans CCUG 32723 CA5MIC0.004 0.004 0.25 None (voriconazole-susceptible strain included as a quality control) a NA, not analyzed. Login to comment