ABCMdb

PMID: 20943283

Han B, Gao G, Wu W, Gao Z, Zhao X, Li L, Qiao R, Chen H, Wei Q, Wu J, Lu D
Association of ABCC2 polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients.
Lung Cancer. 2011 May;72(2):238-43. Epub 2010 Oct 12., [PubMed]

Sentences

No. Mutations Sentence Comment

81 ABCC2 p.Val417Ile ABCC2 p.Val417Ile patients 445 Mean age in years (S.D.) 57 ≤57 years-old 226 (50.8) >57 years-old 219 (49.2) Gender Male 317 (71.2) Female 128 (28.8) Performance status (PS) (n = 444) 0-1 427 (96.0) 2 17(4.0) TNM stage IIIA 43(9.7) IIIB 131 (29.4) IV 271 (60.9) Histologic type Adenocarcinoma 269 (60.4) Squamous cell 88(19.8) Adenosquamocarcinoma 16(3.6) Othersa 72(16.2) Chemotherapy regimens Platinum-vinorelbine 233 (52.4) Platinum-gemcitabine 77(17.3) Platinum-paclitaxel 90 (20.2) Platinum-docetaxel 22(4.9) Other platinum combinations 23(5.2) ABCC2 C-24T C/C 266 (60.3) C/T 159 (36.1) T/T 16(3.6) ABCC2 G1249A (V417I) G/G 353 (81.0) A/G 76(17.4) A/A 7(1.6) ABCC2 C3972T (I1324I) C/C 262 (59.5) C/T 157 (35.7) T/T 21(4.8) a Other carcinomas include mixed cell, neuroendocrine carcinoma or undifferentiated carcinoma. Login to comment 109 ABCC2 p.Val417Ile ABCC2 genotype Responder (CR + PR), n (%) Non-responder (SD + PD), n (%) OR (95% CI)a P-value C-24T 0.032 C/C 55(72.4) 196 (58.3) 1.00 (reference) C/T + T/T 21(27.6) 140 (41.7) 1.84 (1.05-3.23) G1249A (V417I) 0.308 G/G 64(83.8) 267 (80.2) 1.00 (reference) A/G + A/A 12(16.2) 66(19.8) 1.44 (0.72-2.89) C3972T (I1324I) 0.137 C/C 49(67.1) 196 (58.0) 1.00 (reference) C/T + T/T 24(32.9) 142 (42.0) 1.51 (0.88-2.61) Abbreviation: PS, performance status. Login to comment 112 ABCC2 p.Val417Ile ABCC2 genotype Any grade 0-2 thrombocytopenia toxicity, n (%) Any grade 3 or 4 thrombocytopenia toxicity, n (%) OR (95% CI)a P-Valuea C-24T 0.074 C/C 235 (60.9) 11(42.3) 1.00 (reference) C/T + T/T 151 (39.1) 15(57.7) 2.09 (0.93-4.70) G1249A (V417I) G/G 306 (80.3) 23(88.5) 1.00 (reference) 0.309 A/G + A/A 75(19.7) 3(11.5) 0.59 (0.17-2.11) C3972T (I1324I) 0.034 C/C 232 (60.3) 10(38.5) 1.00 (reference) C/T + T/T 153 (39.7) 16(61.5) 2.43 (1.06-5.56) a Data were calculated by unconditional logistic regression, adjusted for performance status and type of treatment regime. Login to comment