PMID: 20938339

Sylvester RK, Steen P, Tate JM, Mehta M, Petrich RJ, Berg A, Kolesar J
Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients.
Anticancer Drugs. 2011 Jan;22(1):104-10., [PubMed]
Sentences
No. Mutations Sentence Comment
101 ABCB1 p.Ser893Ala
X
ABCB1 p.Ser893Ala 20938339:101:322
status: NEW
view ABCB1 p.Ser893Ala details
 Although both patients were Table 1 Summary of genotyping results of the selected SNPsa SNP Case 1 Case 2 Genotype with increased riskb SNP typec Frequency in Caucasiand,e ABCB1 rs1045642 CT CT - Synonymous CC: 0.15, CT: 0.63, TT: 0.22 rs1128503 CT CT - Synonymous CC: 0.35, CT: 0.52, TT: 0.13 rs2032582 GT GT - missense (S893A) GG: 0.32, GT: 0.56, TT: 0.12 GSTP1 rs1695 AG AA AA missense (I105V) AA: 0.33, AG: 0.55, GG: 0.12 MGMT rs12917 CT CT - missense (L84F) CC: 0.78, CT: 0.20, TT: 0.02 rs1803965 GA GA - Synonymous GG: 0.85, GA: 0.14, AA: 0.02 rs2282164 CC CC - missense (W65C) CC 1.00, CG and GG are < 0.001 rs2308318 GG GG - missense (G160R) GG 1.00, AG is 0.007 globally, AA: 0.00 rs2308321 GG AA AG or GG missense (I143V) AA: 0.65, AG: 0.35; GG: 0.007 globally rs2308322 GG GG - missense (P58S) GG, 1.00, GA is 0.003 globally, AA 0.00 rs2308327 AG AA AG or GG missense (K178R) AA: 0.98, AG: 0.02, GG: 0.00 NQO1 rs1800566 GG GG GG missense (P187S) GG: 0.60, AG: 0.37, AA: 0.03 ABCB1, ATB-binding cassette subfamily B member 1; GSTP1, glutathione S-transferases pi 1; MGMT, O6 -methylguanine-DNA-methyltransferase; NQO1, NAD(P)H dehydrogenase (quinone) family; SNPs, single nucleotide polymorphisms; a Bold lettering denotes SNPs, which were found to be non-wild-type for the indicated patient. Login to comment