ABCMdb

PMID: 20799947

Gould NS, Gauthier S, Kariya CT, Min E, Huang J, Brian DJ
Hypertonic saline increases lung epithelial lining fluid glutathione and thiocyanate: two protective CFTR-dependent thiols against oxidative injury.
Respir Res. 2010 Aug 27;11:119., [PubMed]

Sentences

No. Mutations Sentence Comment

48 ABCC7 p.Ser489* C57BL/6J congenic gut-corrected Cftr KO-Tg mice that possess a S489X truncated mutation in the murine equivalent to CFTR and have intestinal specific expression of normal human Cftr driven by the fatty acid binding promoter were originally obtained from Case Western Reserve University`s CF Animal Core, as previously described [18]. Login to comment 187 ABCC7 p.Ser489* The CFTR KO mice utilized in this study possess the S489X truncation mutation resulting in a non functional CFTR. Login to comment