ABCMdb

PMID: 20515567

Chen LM, Xu YH, Zhou CL, Zhao J, Li CY, Wang R
Overexpression of CDR1 and CDR2 genes plays an important role in fluconazole resistance in Candida albicans with G487T and T916C mutations.
J Int Med Res. 2010 Mar-Apr;38(2):536-45., [PubMed]

Sentences

No. Mutations Sentence Comment

62 ABCB1 p.Arg467Lys The Erg11p Y132H, T315A, S405F, G464S, R467K and I471T mutations have all been shown to be associated with azole resistance.22 - 25 Some researchers have demonstrated the structural importance of the Y118 amino acid residue in maintaining C. albicans cytochrome P450 14α-sterol demethylase P450 (CACYP51) activity and determining azole susceptibility.26 The contributions of other mutations such as Y79C, D81G, F126L and V130I to fluconazole resistance are still uncertain. Login to comment 141 ABCB1 p.Arg467Lys 25 Lamb DC, Kelly DE, White TC, et al: The R467K amino acid substitution in Candida albicans sterol 14α-demethylase causes drug resistance through reduced affinity. Login to comment