PMID: 20504240

Park WB, Choe PG, Song KH, Jeon JH, Park SW, Kim HB, Kim NJ, Oh MD, Choe KW
Genetic factors influencing severe atazanavir-associated hyperbilirubinemia in a population with low UDP-glucuronosyltransferase 1A1*28 allele frequency.
Clin Infect Dis. 2010 Jul 1;51(1):101-6., 2010-07-01 [PubMed]
Sentences
No. Mutations Sentence Comment
31 ABCB1 p.Gly211Ala
X
ABCB1 p.Gly211Ala 20504240:31:27
status: NEW
view ABCB1 p.Gly211Ala details
 The UGT1A1*6 polymorphism (G211A, G71R), which is common in some Asians (13%-23%) and rare in Caucasians (0.1%) [3], results in an ~70% reduction in the rate of bilirubin glucuronidation in vitro [11] and is associated with Gilbert syndrome in Asians, irrespective of the UGT1A1*28 allele [6, 12]. Login to comment