PMID: 20331623

Shim HJ, Yun JY, Hwang JE, Bae WK, Cho SH, Lee JH, Kim HN, Shin MH, Kweon SS, Lee JH, Kim HJ, Chung IJ
BRCA1 and XRCC1 polymorphisms associated with survival in advanced gastric cancer treated with taxane and cisplatin.
Cancer Sci. 2010 May;101(5):1247-54. Epub 2010 Mar 12., [PubMed]
Sentences
No. Mutations Sentence Comment
56 ABCB1 p.Ala677Val
X
ABCB1 p.Ala677Val 20331623:56:908
status: NEW
view ABCB1 p.Ala677Val details
ABCB1 p.Ser893Thr
X
ABCB1 p.Ser893Thr 20331623:56:1341
status: NEW
view ABCB1 p.Ser893Thr details
 Polymorphism primer sequences and method of study Genotype Primer and probe Polymorphism Method Reference GSTM1 F: GAGACAGAAGAGGAGAAGATTC R: GCCCAGCTGCATATGGTTGT Null TaqMan RQ (19) GST T1 F: CTTCCAGGAGGCCCATGAG R: CAGGGCATCAGCTTCTGCTT Null TaqMan RQ (19) GSTP1 F: TGGTGGACATGGTGAATGAC R: TGCAGATGCTCACATAGTTGG A / G, Val105Ile HRM ERCC1 F: TTGTCCAGGTGGATGTGGTA R: CCTCGCTGAGGTTTTAGCTG A / C, Intron 5 HRM XRCC3 F: CCATTCCGCTGTGAATTTG R: GAAGGCACTGCTCAGCTCAC C / T, Thr241Met HRM XRCC4 F: AGGCCTGATTCTTCACTACCTG R: GGCTGCTGTTTCTCAGAGTTTC G / T, Ser307Ser HRM XRCC1 F: ATAATACTGACCTTGCGGGACC R: Biotin-ACCCACGAGTCTAGGTCTCAA S: CTGAGGCCGGGGGCT C / T, Arg194Trp PYRO XRCC1 F: TCTCCCTTGGTCTCCAACCT R: AGTAGTCTGCTGGCTCTGG G / A, Arg399Gln RFLP: HpaII (20) BRCA1 F: CCACAGTCGGGAAACAAGCATAGA R: CTTCTGCATTTCCTGGATTTGAAACC C / T, Pro871Leu RFLP: HpaII (21) MTHFR F:CTTTGAGGCTGACCTGAAGC R:TCACAAAGCGGAAGAATGTG C / T, Ala677Val TaqMan RQ TYMS 6 bp F: CAA ATC TGA GGG AGC TGA GT R: CAG ATA AGT GGC AGT ACA GA` Insertion / deletion (3-UTR) EP (22) TYMS 2R3R F: GTG GCT CCT GCG TTT CCC CC R: CCA AGC TTG GCT CCG AGC CGG CCA CAG GCA TGG CGC GG Two or three 28-bp repeats (5-UTR) EP (23) ABCB1 1236 F: TCTTTGTCAC TTTATCCAGC R: TCTCACCATC CCCTCTGT T / C, Gly412Gly RFLP: EcoO191I (24) ABCB1 2677 F: TGCAGGCTATAGGTTCCAGG R: TTTAGTTTGACTCACCTTCCCG G / T / A, Ser893 Thr / Ala RFLP: Ban1, Rsa1 (24) ABCB1 3435 F: TGCTGGTCCTGAAGTTGATCTGTGAAC R: ACATAGGCAGTGACTCGATGAAGGCA C / T, Ile1145 Ile RFLP: Mbo1 (25) EP, electrophoresis on a 6% polyacrylamide gel; HRM, high resolution melter; PSQ, pyrosequencing; RFLP, restriction fragment length polymorphism; TaqMan RQ, TaqMan allelic discrimination assay. Login to comment