PMID: 20212519

Leskela S, Jara C, Leandro-Garcia LJ, Martinez A, Garcia-Donas J, Hernando S, Hurtado A, Vicario JC, Montero-Conde C, Landa I, Lopez-Jimenez E, Cascon A, Milne RL, Robledo M, Rodriguez-Antona C
Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity.
Pharmacogenomics J. 2011 Apr;11(2):121-9. Epub 2010 Mar 9., [PubMed]
Sentences
No. Mutations Sentence Comment
65 ABCB1 p.Asn21Asp
X
ABCB1 p.Asn21Asp 20212519:65:473
status: NEW
view ABCB1 p.Asn21Asp details
 However, its effect on enzyme activity remains unclear.26 On the other hand, CYP3A5 is very polymorphic, and its activity in Caucasians is determined by CYP3A5*3 allele through alternative splicing.37 For the uptake transporters OATP 1B3 and OATP 1B1 we selected missense polymorphisms with reported functional consequences.17 Finally, for ABCB1 we selected the three most studied variants (1236C4T, 2677G4T and 3435C4T)27 associated with altered transport and a missense (N21D) polymorphism described in public databases but not previously studied. Login to comment