PMID: 20177420

Glimelius B, Garmo H, Berglund A, Fredriksson LA, Berglund M, Kohnke H, Bystrom P, Sorbye H, Wadelius M
Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer.
Pharmacogenomics J. 2011 Feb;11(1):61-71. Epub 2010 Feb 23., [PubMed]
Sentences
No. Mutations Sentence Comment
63 ABCB1 p.Ser893Ala
X
ABCB1 p.Ser893Ala 20177420:63:83
status: NEW
view ABCB1 p.Ser893Ala details
 Genotyping of ABCB1 c.2677G4T/A (rs2032582), which leads to a change in amino acid 893 from serine to alanine or threonine, was performed according to Saito et al.44 Allelic discrimination of the synonymous ABCB1 polymorphisms c.1236C4T (rs1128503) and c.3435C4T (rs1045642) was performed using TaqMan SNP Genotyping Assay kits containing primers and probes (C__7586662_10 and C__7586657_1, Applied Biosystems). Login to comment