PMID: 20088754

Li Y, Yuan H, Yang K, Xu W, Tang W, Li X
The structure and functions of P-glycoprotein.
Curr Med Chem. 2010;17(8):786-800., [PubMed]
Sentences
No. Mutations Sentence Comment
165 ABCB1 p.Leu975Cys
X
ABCB1 p.Leu975Cys 20088754:165:261
status: NEW
view ABCB1 p.Leu975Cys details
ABCB1 p.Leu332Cys
X
ABCB1 p.Leu332Cys 20088754:165:244
status: NEW
view ABCB1 p.Leu332Cys details
 In 2002, Loo & Clarke found that with hydrolysis of the first molecule of ATP there is a further conformational change such as an -helix rotation between TM6 and TM12, which can be detected by disulfide cross-linking between cysteines (residue L332C in TM6 and L975C in TM12) [66]. Login to comment