PMID: 19935781

Mueller C, Keeler A, Braag S, Menz T, Tang Q, Flotte TR
Modulation of exaggerated-IgE allergic responses by gene transfer-mediated antagonism of IL-13 and IL-17e.
Mol Ther. 2010 Mar;18(3):511-8. Epub 2009 Nov 24., [PubMed]
Sentences
No. Mutations Sentence Comment
189 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 19935781:189:69
status: NEW
view ABCC7 p.Ser489* details
 The primary Cftr knockout strain used for these studies was the CFTR S489X-/- neo insertion in C57BL/6 mice developed initially at the University of North Carolina24 and then modified with the transgenic overexpression of gut-specific expression of human CFTR from the fatty acid-binding protein promoter in order to prevent intestinal obstruction and improve viability.25 These mice have then been backcrossed 10 generations onto a C57BL/6 mouse. Login to comment 194 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 19935781:194:27
status: NEW
view ABCC7 p.Ser489* details
 Six to eight-week-old Cftr S489X-/-; fatty acid-binding protein human CFTR+/+, and wild-type lit- termatemicewerehousedinthespecificpathogen-freemousecolonyofthe University of Massachusetts Medical School (Worcester, MA) according to National Institutes of Health guidelines and were allowed food and water ad libitum. Login to comment