ABCMdb

PMID: 19925455

Pagano MA, Marin O, Cozza G, Sarno S, Meggio F, Treharne KJ, Mehta A, Pinna LA
Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2.
Biochem J. 2010 Jan 27;426(1):19-29., 2010-02-15 [PubMed]

Sentences

No. Mutations Sentence Comment

51 ABCC7 p.Val510Asp ABCC7 p.Val510Asp Also of note in Figure 1 is the effect of mutating Val510 to aspartate either in the context of a wild-type peptide or its F508 equivalent, the latter combination having been shown to partially restore functionality of CFTR F508 [30]; in our hands this V510D mutation significantly abrogates the inhibitory efficacy of the CFTR F508 peptide, yet has a diametrically opposed effect when present in the wild-type peptide, whose moderate inhibitory efficiency is increased almost equalling that of the CFTR F508 peptide. Login to comment