PMID: 19891558

Roumier C, Cheok MH
Pharmacogenomics in acute myeloid leukemia.
Pharmacogenomics. 2009 Nov;10(11):1839-51., [PubMed]
Sentences
No. Mutations Sentence Comment
194 ABCC8 p.Lys242Gln
X
ABCC8 p.Lys242Gln 19891558:194:101
status: NEW
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 In a European AML study of 360 patients, 2% had a heterozygous P122S variant and 1% had heterozygous Lys242Gln [70]. Login to comment 231 ABCC8 p.Asn676Lys
X
ABCC8 p.Asn676Lys 19891558:231:73
status: NEW
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 An underlying resistance mechanism in patients resistant to PKC412 is an N676K mutation in the N-lobe of the FLT-3 gene [83]. Login to comment