PMID: 19710077

Anderson PL, Aquilante CL, Gardner EM, Predhomme J, McDaneld P, Bushman LR, Zheng JH, Ray M, MaWhinney S
Atazanavir pharmacokinetics in genetically determined CYP3A5 expressors versus non-expressors.
J Antimicrob Chemother. 2009 Nov;64(5):1071-9. Epub 2009 Aug 26., [PubMed]
Sentences
No. Mutations Sentence Comment
224 ABCC1 p.Ala893Ser
X
ABCC1 p.Ala893Ser 19710077:224:42
status: NEW
view ABCC1 p.Ala893Ser details
 However, the T variant in 2677 encodes an Ala893Ser in exon 21, which was associated with increased activity in one in vitro study.41 Another study showed that the T variant in 2677 is associated with higher basal CYP3A4 expression and activity.42 Finally, some investigators raise the possibility that protein folding differences with the variant haplotype (1236T, 2677T, 3435T) could lead to enhanced P-glycoprotein function, depending on the substrate.17 These investigations are consistent with the findings in the present study. Login to comment