PMID: 19587354

Hamming KS, Soliman D, Matemisz LC, Niazi O, Lang Y, Gloyn AL, Light PE
Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.
Diabetes. 2009 Oct;58(10):2419-24. Epub 2009 Jul 8., [PubMed]
Sentences
No. Mutations Sentence Comment
76 ABCC8 p.Ser1237Tyr
X
ABCC8 p.Ser1237Tyr 19587354:76:74
status: NEW
view ABCC8 p.Ser1237Tyr details
 The A site is located close to SUR1 transmembrane segments 14-16, and the S1237Y mutation in this region (Fig. 3A) abolishes A-site drug inhibition (18). Login to comment 78 ABCC8 p.Ser1237Tyr
X
ABCC8 p.Ser1237Tyr 19587354:78:74
status: NEW
view ABCC8 p.Ser1237Tyr details
 The A site is located close to SUR1 transmembrane segments 14-16, and the S1237Y mutation in this region (Fig. 3A) abolishes A-site drug inhibition (18). Login to comment