PMID: 19415824

Ufer M, Mosyagin I, Muhle H, Jacobsen T, Haenisch S, Hasler R, Faltraco F, Remmler C, von Spiczak S, Kroemer HK, Runge U, Boor R, Stephani U, Cascorbi I
Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.
Pharmacogenet Genomics. 2009 May;19(5):353-62., [PubMed]
Sentences
No. Mutations Sentence Comment
27 ABCC2 p.Val417Ile
X
ABCC2 p.Val417Ile 19415824:27:77
status: NEW
view ABCC2 p.Val417Ile details
 Recently, we have observed a significant association of the ABCC2 1249G > A (V417I) polymorphism with reduced oral bioavailability of talinolol presumably as a result of increased MRP2 activity [22]. Login to comment