PMID: 19403599

Aleksandrov AA, Cui L, Riordan JR
Relationship between nucleotide binding and ion channel gating in cystic fibrosis transmembrane conductance regulator.
J Physiol. 2009 Jun 15;587(Pt 12):2875-86. Epub 2009 Apr 29., 2009-06-15 [PubMed]
Sentences
No. Mutations Sentence Comment
136 ABCC7 p.Phe508Ala
X
ABCC7 p.Phe508Ala 19403599:136:137
status: NEW
view ABCC7 p.Phe508Ala details
 All mutants have nearly the same mean open time of 220 ms while mean closed times varied from 230 ms for the wild-type CFTR to 7.8 s for F508A. Login to comment 142 ABCC7 p.Phe1068Trp
X
ABCC7 p.Phe1068Trp 19403599:142:151
status: NEW
view ABCC7 p.Phe1068Trp details
ABCC7 p.Phe1068Met
X
ABCC7 p.Phe1068Met 19403599:142:131
status: NEW
view ABCC7 p.Phe1068Met details
 All mutants at position 1068 have mean open times narrowly distributedaround220mswithmeanclosedtimesranging widely from 100 ms for F1068M to 3.1 s for F1068W. Login to comment