ABCMdb

PMID: 19339490

Wellhauser L, Kim Chiaw P, Pasyk S, Li C, Ramjeesingh M, Bear CE
A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability.
Mol Pharmacol. 2009 Jun;75(6):1430-8. Epub 2009 Apr 1., [PubMed]

Sentences

No. Mutations Sentence Comment

208 ABCC7 p.Val510Cys ABCC7 p.Ala1067Cys It is noteworthy that Loo et al. (2008) and Serohijos et al. (2008) showed that deletion of Phe508 impairs the chemical cross-linking that normally occurs between a non-native cysteine residue incorporated into NBD1, in the proximity of Phe508 (V510C), and a non-native cysteine introduced into the fourth intracellular loop (A1067C) Fig. 5. Login to comment 223 ABCC7 p.Ala274Cys Loo et al. (2008) also found that deletion of Phe508 disrupted the chemical cross-linking that normally occurred between non-native cysteines of MSD1 (A274C) and NBD2 (Loo et al., 2008) and cross-linking between non-native cysteines introduced into transmembrane helices 6 (MSD1) and 7 or 12 (MSD2) (Wang et al., 2007). Login to comment