ABCMdb

PMID: 19167254

Huang SY, Bolser D, Liu HY, Hwang TC, Zou X
Molecular modeling of the heterodimer of human CFTR's nucleotide-binding domains using a protein-protein docking approach.
J Mol Graph Model. 2009 Apr;27(7):822-8. Epub 2008 Dec 24., [PubMed]

Sentences

No. Mutations Sentence Comment

201 ABCC7 p.Gly551Asp ABCC7 p.Gly1349Asp The interactions between the Q-loop and signature motif may explain why G551D and G1349D, the CF-associated mutations in the signature motif, influence genistein`s effects [49,13]. Login to comment 205 ABCC7 p.Gly551Asp ABCC7 p.Gly1349Asp The interactions between the Q-loop and signature motif may explain why G551D and G1349D, the CF-associated mutations in the signature motif, influence genistein`s effects [49,13]. Login to comment 217 ABCC7 p.Phe494Gly Our preliminary study with F494G-CFTR using whole-cell electrophysiological recording showed that indeed the apparent affinity of genistein was lowered to 25.3 mM, compared to 4.4 mM for wild-type CFTR (M. Li and T.-C. Hwang, unpublished data). Login to comment 221 ABCC7 p.Phe494Gly Our preliminary study with F494G-CFTR using whole-cell electrophysiological recording showed that indeed the apparent affinity of genistein was lowered to 25.3 mM, compared to 4.4 mM for wild-type CFTR (M. Li and T.-C. Hwang, unpublished data). Login to comment