ABCMdb

PMID: 19117087

Lo M, Tsao MS, Hedley D, Ling V
Gene expression profiling of adenosine triphosphate-binding cassette transporters in response to K-ras activation and hypoxia in human pancreatic cancer cell cultures.
Pancreas. 2009 Jan;38(1):85-93., [PubMed]

Sentences

No. Mutations Sentence Comment

129 ABCB6 p.Gly12Val The K-ras point mutation G12V, which results in a constitutively active K-ras protein, is present in over 90% of PC and occurs at a very early stage of cancer development.24Y26 Immortalized HPDE cells stably transfected with the K-rasG12V oncogene are weakly tumorigenic and exhibit gene expression changes that closely resemble those observed in pancreatic ductal adenocarcinomas.15 Specifically, microarray expression profiling studies identified 584 genes whose expression levels were specifically up-regulated by the K-ras oncogene, of which 42 have been reported previously as differentially overexpressed in PC cell lines or primary tumors.15 However, none of the 42 genes mentioned in this report were from the ABC transporter family.15 It is also unknown whether any of the remaining 542 genes might be from the ABC transporter family. Login to comment