PMID: 19093297

Sharma S, Das M, Kumar A, Marwaha V, Shankar S, Aneja R, Grover R, Arya V, Dhir V, Gupta R, Kumar U, Juyal RC, B K T
Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians.
Pharmacogenet Genomics. 2008 Dec;18(12):1041-9., [PubMed]
Sentences
No. Mutations Sentence Comment
70 ABCC1 p.Ala893Ser
X
ABCC1 p.Ala893Ser 19093297:70:398
status: NEW
view ABCC1 p.Ala893Ser details
ABCC1 p.Ala893Thr
X
ABCC1 p.Ala893Thr 19093297:70:409
status: NEW
view ABCC1 p.Ala893Thr details
 Gene polymorphisms and MTX response in RA Sharma et al. 1043 published single nucleotide polymorphisms One commonly investigated SNP rs1051266 (80 G > A, Arg27His, exon 3) of RFC gene; a total of eight SNPs from MDR1 gene including one promoter SNP rs3213619 ( - 129T > C); three commonly analysed exonic SNPs rs1128503 (1236C > T, Gly411Gly, exon 12); triallelic SNP rs2032582 (2677G> T, G > A, Ala893Ser, Ala893Thr, exon 21); and rs1045642 (3435C > T, Ile1145Ile, exon 26); and four splice variants rs28381943, rs2235064, rs2235044 and rs2235032; three SNPs from GGH gene including one promoter SNP rs3758149 ( - 401C > T); two exonic SNPs rs1800909 (16T > C, Cys6Arg, exon 1); and rs11545078 (452C > T, Thr151Ile, exon 5) and one tag SNP rs1544105 G > A through hapmap database (release #21) in the vicinity of FPGS gene were genotyped in the sample set. Login to comment