ABCMdb

PMID: 19023099

Luke MM, O'Meara ES, Rowland CM, Shiffman D, Bare LA, Arellano AR, Longstreth WT Jr, Lumley T, Rice K, Tracy RP, Devlin JJ, Psaty BM
Gene variants associated with ischemic stroke: the cardiovascular health study.
Stroke. 2009 Feb;40(2):363-8. Epub 2008 Nov 20., [PubMed]

Sentences

No. Mutations Sentence Comment

12 ABCG2 p.Val12Met The Val12Met SNP in ABCG2 was associated with stroke in both white (hazard ratio, 1.46; 90% CI, 1.05 to 2.03) and black (hazard ratio, 3.59; 90% CI, 1.11 to 11.6) participants of CHS. Login to comment 14 ABCG2 p.Val12Met Conclusions-The Val12Met SNP in ABCG2 (encoding a transporter of sterols and xenobiotics) was associated with incident ischemic stroke in white and black participants of CHS. Login to comment 76 ABCG2 p.Val12Met ABCG2 Val12Met (rs2231137) was the only SNP associated with incident ischemic stroke in both white and black participants of CHS. Login to comment 82 ABCG2 p.Val12Met The most notable finding, consistent in both whites and blacks, was the association between the Val allele of ABCG2 Val12Met and increased risk of incident ischemic stroke. Login to comment 84 ABCG2 p.Val12Met The first of these 3 gene variants was the Val allele of ABCG2 Val12Met (rs2231137). Login to comment 97 ABCG2 p.Val12Met The Val Allele Homozygotes of ABCG2 Val12Met, Compared With the Met Allele Carriers Are Associated With Increased Risk of Incident Ischemic Stroke in Both White and Black Participants of CHS Model 1* Model 2* ABCG2 Genotype Events, n Total, n HR (90% CI) P HR (90% CI) P White ValVal 370 3398 1.58 (1.12-2.23) 0.02 1.50 (1.06-2.12) 0.03 ValMetϩMetMet 24 335 1 (Reference) 1 (Reference) ValMet 23 321 MetMet 1 14 Black ValVal 66 592 3.80 (1.16-12.4) 0.03 3.62 (1.11-11.9) 0.04 ValMetϩMetMet 2 70 1 (Reference) 1 (Reference) ValMet 2 69 MetMet 0 1 *Model 1 was adjusted for baseline age and sex. Login to comment 100 ABCG2 p.Val12Met Comparison of Kaplan-Meier estimates of the cumulative incidence of ischemic stroke among Val allele homozygotes of the ABCG2 Val12Met and among Met allele carriers in white (A) and in black (B) participants of CHS. Login to comment 113 ABCG2 p.Val12Met Notably, the Val allele of the Val12Met SNP in ABCG2 (which encodes a transporter of sterols and anticancer drugs) was associated with increased risk of incident ischemic stroke in both white and black participants of CHS. Login to comment