ABCMdb

PMID: 19020075

Jordan IK, Kota KC, Cui G, Thompson CH, McCarty NA
Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters.
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18865-70. Epub 2008 Nov 19., 2008-12-02 [PubMed]

Sentences

No. Mutations Sentence Comment

95 ABCC7 p.Asp993Arg ABCC7 p.Glu1104Arg ABCC7 p.Arg352Glu ABCC7 p.Arg352Glu ABCC7 p.Arg352Glu Isolated bursts of channel activity from oocytes expressing WT-CFTR, R352E-CFTR, R352E/E1104R-CFTR, and R352E/D993R-CFTR. Login to comment 99 ABCC7 p.Glu1104Arg ABCC7 p.Arg352Glu ABCC7 p.Arg352Glu Channels bearing the R352E mutation, or the double mutant R352E/E1104R, exhibited frequent transitions to subconductance levels. Login to comment 100 ABCC7 p.Asp993Arg ABCC7 p.Arg352Glu In contrast, WT-CFTR channels, and channels bearing the revertant mutation R352E/D993R, primarily exhibit transitions to the full conductance level. Login to comment 131 ABCC7 p.Asp993Arg ABCC7 p.Asp993Arg ABCC7 p.Arg352Glu ABCC7 p.Arg352Glu ABCC7 p.Arg352Lys In contrast, approximately wild-type channel behavior is retained in R352K-CFTR and the charge-swapping double mutant, R352E/D993R-CFTR (Fig. 3). Login to comment