PMID: 18981587

Fujita K, Nagashima F, Yamamoto W, Endo H, Sunakawa Y, Yamashita K, Ishida H, Mizuno K, Matsunaga M, Araki K, Tanaka R, Ichikawa W, Miya T, Narabayashi M, Akiyama Y, Kawara K, Ando Y, Sasaki Y
Association of ATP-binding cassette, sub-family C, number 2 (ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI).
Biol Pharm Bull. 2008 Nov;31(11):2137-42., [PubMed]
Sentences
No. Mutations Sentence Comment
40 ABCC2 p.Val417Ile
X
ABCC2 p.Val417Ile 18981587:40:96
status: NEW
view ABCC2 p.Val417Ile details
 Six polymorphisms (-1549GϾA, -1023GϾA, -1019AϾG, -24CϾT, 1249GϾA [V417I] and 3972CϾT [I324I], based on assigning the A in the translation start codon as ϩ1) were examined by direct DNA sequencing. Login to comment 88 ABCC2 p.Val417Ile
X
ABCC2 p.Val417Ile 18981587:88:69
status: NEW
view ABCC2 p.Val417Ile details
 The presence of the 1249GϾA that causes the amino acid change (V417I) resulted in the lower AUC of irinotecan. Login to comment