PMID: 18846238

Chen J, Kinter M, Shank S, Cotton C, Kelley TJ, Ziady AG
Dysfunction of Nrf-2 in CF epithelia leads to excess intracellular H2O2 and inflammatory cytokine production.
PLoS One. 2008;3(10):e3367. Epub 2008 Oct 10., [PubMed]
Sentences
No. Mutations Sentence Comment
86 ABCC7 p.Arg117His
X
ABCC7 p.Arg117His 18846238:86:215
status: NEW
view ABCC7 p.Arg117His details
 To test whether differences in the redox proteins observed in CF cells extended to an in vivo model of CF, we examined protein expression, by 2-D gel analysis, in the excised nasal epithelia (NE) and whole lungs of R117H mutant mice compared with normal littermates. Login to comment 358 ABCC7 p.Arg117His
X
ABCC7 p.Arg117His 18846238:358:33
status: NEW
view ABCC7 p.Arg117His details
ABCC7 p.Arg117His
X
ABCC7 p.Arg117His 18846238:358:34
status: NEW
view ABCC7 p.Arg117His details
 The B6.129S6-Cftrtm2Mrc mice are R117H murine Cftr mutants that have been back-crossed into the C57BL6j background [46]. Login to comment