PMID: 18799655

Seavilleklein G, Amer N, Evagelidis A, Chappe F, Irvine T, Hanrahan JW, Chappe V
PKC phosphorylation modulates PKA-dependent binding of the R domain to other domains of CFTR.
Am J Physiol Cell Physiol. 2008 Nov;295(5):C1366-75. Epub 2008 Sep 17., [PubMed]
Sentences
No. Mutations Sentence Comment
256 ABCC7 p.Ser686Ala
X
ABCC7 p.Ser686Ala 18799655:256:94
status: NEW
view ABCC7 p.Ser686Ala details
ABCC7 p.Ser790Ala
X
ABCC7 p.Ser790Ala 18799655:256:300
status: NEW
view ABCC7 p.Ser790Ala details
ABCC7 p.Thr791Ala
X
ABCC7 p.Thr791Ala 18799655:256:306
status: NEW
view ABCC7 p.Thr791Ala details
ABCC7 p.Ser809Ala
X
ABCC7 p.Ser809Ala 18799655:256:312
status: NEW
view ABCC7 p.Ser809Ala details
ABCC7 p.Ser707Ala
X
ABCC7 p.Ser707Ala 18799655:256:294
status: NEW
view ABCC7 p.Ser707Ala details
 S686 is a likely candidate to mediate stimulated PKC-dependent interactions since mutation of Ser686 to alanine in the full-length CFTR channel dramatically reduced CFTR activation to the level of 9CA-CFTR (5), whereas mutation of more distal PKC sites in the RD had no effect on the function (S707A/S790A/T791A/S809A). Login to comment