ABCMdb

PMID: 18782758

Hozoji M, Munehira Y, Ikeda Y, Makishima M, Matsuo M, Kioka N, Ueda K
Direct interaction of nuclear liver X receptor-beta with ABCA1 modulates cholesterol efflux.
J Biol Chem. 2008 Oct 31;283(44):30057-63. Epub 2008 Sep 9., [PubMed]

Sentences

No. Mutations Sentence Comment

191 ABCA1 p.Leu2247Ala ABCA1 p.Leu2247Ala The coexpression of LXRbeta did not retard the degradation of ABCA1(L2247A), whereas the coexpression of ॷ1-syntrophin retarded the degradation of ABCA1(L2247A) (supplemental Fig. 3, b and c). Login to comment 192 ABCA1 p.Leu2247Ala ABCA1 p.Leu2247Ala ABCA1 p.Leu2247Ala The coexpression of LXRbeta did not retard the degradation of ABCA1(L2247A), whereas the coexpression of ␣1-syntrophin retarded the degradation of ABCA1(L2247A) (supplemental Fig. 3, b and c). Login to comment 193 ABCA1 p.Leu2247Ala ABCA1 p.Leu2247Ala These results suggest that the amino acid substitution L2247A does not alter total protein conformation but rather specifically affects the interaction with LXRbeta. Login to comment 194 ABCA1 p.Leu2247Ala ABCA1(L2247A) showed significant apoA-I-dependent cholesterol efflux, and the addition of TO901317 did not affect it even when LXRbeta was coexpressed (supplemental Fig. 3d). Login to comment