ABCMdb

PMID: 18758683

Chistiakov DA, Potapov VA, Khodirev DC, Shamkhalova MS, Shestakova MV, Nosikov VV
Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes.
Acta Diabetol. 2009 Mar;46(1):43-9. Epub 2008 Aug 29., [PubMed]

Sentences

No. Mutations Sentence Comment

107 ABCC8 p.Ala1369Ser It is possible that both E23K and A1369S could interact in underlying Table 4 Association of the A/G R1273R ABCC8 variant with glucose tolerance and b-cell function Characteristics T2D (n = 129) Control (n = 117) GG (n = 41) AA + AG (n = 88) P value GG (n = 71) AA + AG (n = 46) P value Fasting plasma glucose (mmol/l) 9.6 ± 1.8 10.5 ± 1.7 0.069 5.5 ± 0.6 6.0 ± 0.4 0.42 2 h plasma glucose (mmol/l) 12.0 ± 1.0 13.1 ± 1.3 0.031 6.4 ± 0.7 7.5 ± 0.8 0.052 Fasting serum insulin (mU/l) 14.1 ± 7.6 15.3 ± 7.7 0.027 9.8 ± 6.6 10.7 ± 5.9 0.032 2 h serum insulin (mU/l) 81.4 ± 34.9 88.0 ± 32.9 0.018 46.8 ± 19.7 53.4 ± 20.1 0.044 HOMA-b 46.2 ± 20.8 43.7 ± 22.9 0.095 98.0 ± 46.9 85.6 ± 45.5 0.0015 Table 5 Carriage of the ''double risk`` genotype (K/K of the E23K KCNJ11 and A/A of the R1273R ABCC8), glucose tolerance and b-cell function Characteristics T2D (n = 129) Control (n = 117) KK/AA (n = 12) Others (n = 117) P value KK/AA (n = 4) Others (n = 111) P value Fasting plasma glucose (mmol/l) 10.6 ± 2.1 9.6 ± 1.6 0.28 6.1 ± 0.7 5.7 ± 0.5 0.48 2 h plasma glucose (mmol/l) 11.9 ± 1.5 12.6 ± 1.1 0.33 7.7 ± 0.8 6.7 ± 0.7 0.13 Fasting serum insulin (mU/l) 16.2 ± 8.1 14.6 ± 7.6 0.022 10.5 ± 6.3 10.2 ± 6.2 0.65 2 h serum insulin (mU/l) 91.5 ± 36.6 82.9 ± 31.6 0.0085 54.8 ± 19.3 47.9 ± 20.0 0.096 HOMA-b 45.6 ± 21.3 47.9 ± 22.8 0.14 80.8 ± 44.2 92.8 ± 46.5 0.0011 susceptibility toT2D on the region 11p15.1. Login to comment 108 ABCC8 p.Ala1369Ser It is possible that both E23K and A1369S could interact in underlying Table 4 Association of the A/G R1273R ABCC8 variant with glucose tolerance and b-cell function Characteristics T2D (n = 129) Control (n = 117) GG (n = 41) AA + AG (n = 88) P value GG (n = 71) AA + AG (n = 46) P value Fasting plasma glucose (mmol/l) 9.6 &#b1; 1.8 10.5 &#b1; 1.7 0.069 5.5 &#b1; 0.6 6.0 &#b1; 0.4 0.42 2 h plasma glucose (mmol/l) 12.0 &#b1; 1.0 13.1 &#b1; 1.3 0.031 6.4 &#b1; 0.7 7.5 &#b1; 0.8 0.052 Fasting serum insulin (mU/l) 14.1 &#b1; 7.6 15.3 &#b1; 7.7 0.027 9.8 &#b1; 6.6 10.7 &#b1; 5.9 0.032 2 h serum insulin (mU/l) 81.4 &#b1; 34.9 88.0 &#b1; 32.9 0.018 46.8 &#b1; 19.7 53.4 &#b1; 20.1 0.044 HOMA-b 46.2 &#b1; 20.8 43.7 &#b1; 22.9 0.095 98.0 &#b1; 46.9 85.6 &#b1; 45.5 0.0015 Table 5 Carriage of the ''double risk`` genotype (K/K of the E23K KCNJ11 and A/A of the R1273R ABCC8), glucose tolerance and b-cell function Characteristics T2D (n = 129) Control (n = 117) KK/AA (n = 12) Others (n = 117) P value KK/AA (n = 4) Others (n = 111) P value Fasting plasma glucose (mmol/l) 10.6 &#b1; 2.1 9.6 &#b1; 1.6 0.28 6.1 &#b1; 0.7 5.7 &#b1; 0.5 0.48 2 h plasma glucose (mmol/l) 11.9 &#b1; 1.5 12.6 &#b1; 1.1 0.33 7.7 &#b1; 0.8 6.7 &#b1; 0.7 0.13 Fasting serum insulin (mU/l) 16.2 &#b1; 8.1 14.6 &#b1; 7.6 0.022 10.5 &#b1; 6.3 10.2 &#b1; 6.2 0.65 2 h serum insulin (mU/l) 91.5 &#b1; 36.6 82.9 &#b1; 31.6 0.0085 54.8 &#b1; 19.3 47.9 &#b1; 20.0 0.096 HOMA-b 45.6 &#b1; 21.3 47.9 &#b1; 22.8 0.14 80.8 &#b1; 44.2 92.8 &#b1; 46.5 0.0011 susceptibility toT2D on the region 11p15.1. Login to comment