ABCMdb

PMID: 18723777

Yang Z, Wu D, Bui T, Ho RJ
A novel human multidrug resistance gene MDR1 variant G571A (G191R) modulates cancer drug resistance and efflux transport.
J Pharmacol Exp Ther. 2008 Nov;327(2):474-81. Epub 2008 Aug 22., [PubMed]

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No. Mutations Sentence Comment

0 ABCB1 p.Gly191Arg A Novel Human Multidrug Resistance Gene MDR1 Variant G571A (G191R) Modulates Cancer Drug Resistance and Efflux Transport Ziping Yang, Daniel Wu, Tot Bui, and Rodney J. Y. Ho Department of Pharmaceutics (Z.Y., T.B., R.J.Y.H.) and Medicine (D.W.), University of Washington, Seattle, Washington Received March 6, 2008; accepted August 21, 2008 ABSTRACT The human multidrug resistance gene MDR1 encodes a membrane-bound transporter P-glycoprotein (Pgp) that confers the drug resistance of cancer cells by mediating an ATP-dependent drug efflux transport. Login to comment 3 ABCB1 p.Gly191Arg Because this nucleotide modification gives rise to an amino acid change from Gly to Arg at the 191 amino acid position of Pgp, we have developed and characterized the functional affect of the G571A variant in stable, recombinant cells. Login to comment 34 ABCB1 p.Gly191Arg In this report, we have characterized a new MDR1 variation, G571A, which has given rise to G191R amino acid transition. Login to comment 144 ABCB1 p.Gly191Arg The G3A transition at position 571 translates into an amino acid change from Gly to Arg at position 191 of the human MDR1 protein Pgp. Login to comment