PMID: 18708750

Masia R, Caputa G, Nichols CG
Regulation of KATP channel expression and activity by the SUR1 nucleotide binding fold 1.
Channels (Austin). 2007 Jul-Aug;1(4):315-23. Epub 2007 Sep 25., [PubMed]
Sentences
No. Mutations Sentence Comment
142 ABCC8 p.Val187Asp
X
ABCC8 p.Val187Asp 18708750:142:157
status: NEW
view ABCC8 p.Val187Asp details
ABCC8 p.Ala116Pro
X
ABCC8 p.Ala116Pro 18708750:142:147
status: NEW
view ABCC8 p.Ala116Pro details
 The ubiquitination‑proteasomal pathway of degradation may be involved: this is the mechanism that underlies the effects of the PHHI mutants A116P and V187D.26 However, the proteasomal inhibitor MG‑132 failed to rescue total DNBF1 protein levels, and incubation with sulfonylureas, which facilitates SUR1 folding and prevents its degradation, was also without effect. Login to comment