ABCMdb

PMID: 18617650

Murphy AJ, Woollard KJ, Hoang A, Mukhamedova N, Stirzaker RA, McCormick SP, Remaley AT, Sviridov D, Chin-Dusting J
High-density lipoprotein reduces the human monocyte inflammatory response.
Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2071-7. Epub 2008 Jul 10., [PubMed]

Sentences

No. Mutations Sentence Comment

19 ABCA1 p.Arg1068His Study Subjects: Healthy and R1068H Tangier Family The study was approved by the Human Ethics committees of the Alfred Hospital and the University of Otago; informed consent was obtained from all donors. Login to comment 26 ABCA1 p.Arg1068His Study Subjects: Healthy and R1068H Tangier Family The study was approved by the Human Ethics committees of the Alfred Hospital and the University of Otago; informed consent was obtained from all donors. Login to comment 97 ABCA1 p.Arg1068His Tangier Patient Derived Monocytes For simplification of comparison between members of the R1068H Tangier family, results are expressed as percentage of CD11b expression after activation with PMA. Login to comment 104 ABCA1 p.Arg1068His Tangier Patient Derived Monocytes For simplification of comparison between members of the R1068H Tangier family, results are expressed as percentage of CD11b expression after activation with PMA. Login to comment 131 ABCA1 p.Arg1068His Finally, we explored the antiinflammatory role of HDL and apoA-I in a Tangier disease subject along with a heterozygote subject and an unaffected member from the R1068H family.48 Tangier disease patients have a dysfunctional ABCA1 unable to support cholesterol efflux to apoA-I.49 The response of monocytes from the unaffected family member was similar to that of healthy subjects, monocytes from the heterozygote subject responded to both HDL and apoA-I albeit less than compared to monocytes of unaffected family member. Login to comment 138 ABCA1 p.Arg1068His ABCA1 p.Arg1068His Finally, we explored the antiinflammatory role of HDL and apoA-I in a Tangier disease subject along with a heterozygote subject and an unaffected member from the R1068H family.48 Tangier disease patients have a dysfunctional ABCA1 unable to support cholesterol efflux to apoA-I.49 The response of monocytes from the unaffected family member was similar to that of healthy subjects, monocytes from the heterozygote subject responded to both HDL and apoA-I albeit less than compared to monocytes of unaffected family member. Login to comment 145 ABCA1 p.Arg1068His Acknowledgments We acknowledge Rachel Brace for her efforts in helping with the blood collection and providing medical care for the R1068H family. Login to comment