PMID: 18577180

Dunkel N, Blass J, Rogers PD, Morschhauser J
Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains.
Mol Microbiol. 2008 Aug;69(4):827-40. Epub 2008 May 27., [PubMed]
Sentences
No. Mutations Sentence Comment
63 ABCB1 p.Ala1005Cys
X
ABCB1 p.Ala1005Cys 18577180:63:86
status: NEW
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 Allele 1 contained a C1079T exchange that caused a T360I mutation and allele 2 had an A1005C substitution that resulted in a K335N mutation in Mrr1p. Login to comment 186 ABCB1 p.Arg467Lys
X
ABCB1 p.Arg467Lys 18577180:186:116
status: NEW
view ABCB1 p.Arg467Lys details
 It was previously shown that DSY292 has acquired a Y132H mutation in one ERG11 allele, in addition to the G464S and R467K mutations that were already present in both ERG11 alleles of the matched isolate DSY291 (Sanglard et al., 1998). Login to comment