PMID: 18444945

Grinyo J, Vanrenterghem Y, Nashan B, Vincenti F, Ekberg H, Lindpaintner K, Rashford M, Nasmyth-Miller C, Voulgari A, Spleiss O, Truman M, Essioux L
Association of four DNA polymorphisms with acute rejection after kidney transplantation.
Transpl Int. 2008 Sep;21(9):879-91. Epub 2008 Apr 25., [PubMed]
Sentences
No. Mutations Sentence Comment
74 ABCB1 p.Asn21Asp
X
ABCB1 p.Asn21Asp 18444945:74:48
status: NEW
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 A417G (exon 28)a,b (0.87) rs3842 (0.86)g A61Gc (N21D) (0.91) rs9282564 (0.91)e C1236Ta (0.6) rs1128503 (0.61)e G2677T/Ac (0.58) rs2032582 (0.46)e Multi-drug resistance associated protein 2/adenosine triphosphate-binding cassette, subfamily c, member 2 (MRP2/ABCC2) T3972Cc Exon 28 (0.64) rs3740066 (0.66)e MRP2 is involved in the biliary excretion of mycophenolic acid glucuronide. Login to comment 121 ABCB1 p.Asn21Asp
X
ABCB1 p.Asn21Asp 18444945:121:237
status: NEW
view ABCB1 p.Asn21Asp details
 Gene position and genotypes BPAR at 12 months No. patients BPAR incidence (%) Odds ratio P-value* CYP3A4 A-392G GG or AG 20 25.0 0.960 0.942 AAà 195 28.7 - CYP3A5 A6986G AA or AG 37 24.3 0.790 0.587 GGà 186 28.5 - ABCB1 A61G (N21D) GG or AG 37 32.4 1.46 0.362 AAà 180 26.7 - C3435T TT 53 37.7 4.19 0.0099 CT 117 29.9 2.6 CCà 56 16.1 - A417G GG or AG 53 18.9 0.519 0.099 AAà 167 29.9 - C1236T TT 41 43.9 3.9 0.009 CT 103 27.2 1.64 CC 87 20.7 - G2677T/A TT 39 43.6 4.93 0.003 GT 103 29.1 2.37 GA or TA 10 10 0.446 GG 73 17.8 - MRP2 G5`reg 6170A GG 40 27.5 1.26 0.853 AG 104 28.8 1.18 AAà 76 26.3 - T3600A AA or AT 30 16.7 0.363 0.053 TTà 189 29.1 - T3972C TT 31 25.8 1.38 0.63 CT 96 30.2 1.37 CCà 94 24.5 - IMPDH1 G1320A AA 15 33.3 1.0 0.571 AG 67 23.9 0.687 GGà 134 29.1 - IMPDH2 T3757C CC or CT 28 46.4 3.39 0.006 TTà 193 24.9 - Table 3. continued Gene position and genotypes BPAR at 12 months No. patients BPAR incidence (%) Odds ratio P-value* IL-2 T-330G GG 24 25 0.892 0.919 GT 94 28.7 1.06 TTà 105 27.6 - G114T TT 18 44.4 3.1 0.107 GT 97 26.8 0.885 GGà 109 25.7 - IL-10 C-592A AA 18 55.6 4.55 0.024 AC 72 25 0.897 CCà 127 25.2 - A-1082G GG 46 28.3 0.940 0.550 AG 105 23.8 0.688 AAà 69 33.3 - C-819T TT 13 53.8 4.23 0.104 CT 68 26.5 1.06 CC 119 24.4 - C851T CT or TT 6 16.7 0.460 0.465 CC 190 26.8 - TGF-b1 C869T (P10L) CC 37 29.7 1.40 0.214 CT 103 33 1.86 TTà 84 21.4 - C915G (R25P) CC or CG 37 32.4 1.2 0.662 GGà 187 27.8 - TNF-a G308A GA or AA 52 38.5 2.18 0.030 GG 170 24.7 - *P-value for the association test derived from the logistic regression using recipient age, gender, treatment group and donor type as covariates (see Materials and methods). Login to comment