PMID: 18424454

Levran O, O'Hara K, Peles E, Li D, Barral S, Ray B, Borg L, Ott J, Adelson M, Kreek MJ
ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence.
Hum Mol Genet. 2008 Jul 15;17(14):2219-27. Epub 2008 Apr 17., 2008-07-15 [PubMed]
Sentences
No. Mutations Sentence Comment
62 ABCB1 p.Ser893Ala
X
ABCB1 p.Ser893Ala 18424454:62:45
status: NEW
view ABCB1 p.Ser893Ala details
 SNP rs2032582 (2677G/T/A) is non-synonymous (Ser893Ala/Thr), SNPs rs1045642 (3435C.T) and rs1128503 (1236C.T) are synonymous and the other six SNPs are intronic. Login to comment 89 ABCB1 p.Ser893Ala
X
ABCB1 p.Ser893Ala 18424454:89:352
status: NEW
view ABCB1 p.Ser893Ala details
 ABCB1 single nucleotide polymorphisms (SNPs) analyzed in this study No. SNP Alleles Positiona Amino acid change Exon/intron (i) MAFb Map positionc HWE P-valued 1 rs1045642 C/T 3435 Ile1145Ile 26 0.45 86976581 0.8 2 rs6949448 A/G i25 0.43 86979750 0.7 3 rs2235067 G/A i22 0.07 86987858 0.8 4 rs2032583 C/T i21 0.08 86998497 0.8 5 rs2032582 G/T (A) 2677 Ser893Ala (Thr) 21 0.43 (0.02) 86998554 0.7 6 rs1922242 A/T i16 0.50 87011603 0.3 7 rs1128503 C/T 1236 Gly412Gly 12 0.42 87017537 0.6 8 rs2520464 A/G i4 0.45 87039022 0.6 9 rs3789243 C/T i3 0.49 87058822 0.4 HWE, Hardy-Weinberg equilibrium. Login to comment