PMID: 18397960

Kis E, Nagy T, Jani M, Molnar E, Janossy J, Ujhellyi O, Nemet K, Heredi-Szabo K, Krajcsi P
Leflunomide and its metabolite A771726 are high affinity substrates of BCRP: implications for drug resistance.
Ann Rheum Dis. 2009 Jul;68(7):1201-7. Epub 2008 Apr 8., [PubMed]
Sentences
No. Mutations Sentence Comment
39 ABCG2 p.Lys86Met
X
ABCG2 p.Lys86Met 18397960:39:133
status: VERIFIED
view ABCG2 p.Lys86Met details
 The insect membrane vesicle preparations were obtained using recombinant baculoviruses encoding wild-type human BCRP, defective BCRP-K86M mutant (carrying a mutation at a crucial position of the catalytic center of ATP binding and cleavage) and MDR1.21 Sf9 cells were cultured and infected with recombinant baculovirus stocks as described earlier. Login to comment